They are seen in the Biosphere. The Griptian has an armored back, a tail and giant claws. It is capable of attacking by ramming into Samus while rolling around, as well as slashing and tackling her to the ground. It resembles an Arachnus in appearance and attack.
When the Griptian is rolling, it can easily be dislodged with a Bomb or a Charge Beam shot, however, the Griptian's armor will deflect the attack, nullifying damage. Samus can easily defeat it by shooting it with a Missile or perform an Overblast to knock it down and finish it off with a Lethal Strike, or simply dodge its pounce which primes for a Lethal Strike as well.
Mighty Griptians are stronger than the standard Griptians.
"Griptians are armadillo type creatures that attack by rolling into a ball and charging. They can burrow into the ground and appear under Samus to tackle her."
- Concept art states that the Griptian was transformed into a monster as an experimental test subject.
- When Overblast is attempted but Samus fails to fire on time, the Griptian will throw her off but no damage is incurred.
- A single Griptian can be found ensnared in Kihunter webbing in the underground cavern, directly outside their nest in the Biological Experiment Floor.
- Art of a Griptian is featured on one side of a Metroid: Other M poster in Nintendo Power's September 2010 issue. The same art is also included in the Metroid: Other M Art Folio.
- The Griptian's Japanese name includes the kanji 星人, which is shared with Zebesian, Kyratian, and Ghalmanian. Similarly, their English names end with the -ian suffix. Since this name indicates that the Zebesian is an inhabitant of Zebes, this may imply that Griptian are native to a (currently-unseen) planet named Gript (グリプト).